Comments on Science and Technology
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While Skene and Henikoff described this benefit of CUT&RUN, it is not easy to find a publication that takes advantage of that. But Torres-Campana et al. use it in a great paper in PLOS Genetics, 2022. A key gene in fruit fly reproduction, DHD (deadhead), is included in a very small heterochromatin domain and at…
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Great paper in Cancer Discovery: Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes, PMID: 36399432. The precision medicine challenge in prostate cancer seems to be that in the course of therapy that targets androgen receptor pathway, prostate cancer can mutate into neuroendocrine type that does not use that pathway…
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Very interesting lecture by Dr. Sadeh for Boston Epigenetic Society about the successes of H3K4me3 ChIPseq of whole blood samples as a cancer diagnostic tool. Diagnosis without invasive biopsies may revolutionize precision medicine. Of course, it is well to learn about challenges that remain. Dr. Sadeh showed how neuralized subtypes of SCLC are identified with…
Jieun Jeong (정지은), Ph.D. 