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Glioblastoma proliferates by stealing mitochondria from astrocytes
Read more: Glioblastoma proliferates by stealing mitochondria from astrocytesTo proliferate and self-renew, cells of glioblastoma (GBM) need significantly faster metabolism than their ancestral neuronal cells, and for that, they take mitochondria from glial cells, mostly from astrocytes. This is achieved by “hijacking” the healthy mechanism of astrocyte reactivity: growth factor GAP43 produced by GBM cells stimulates astrocytes to produce microtubes that connect their…
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Dormant cancer cells floating like mines with YAP/TAZ trigger
Read more: Dormant cancer cells floating like mines with YAP/TAZ triggerYAP/TAZ can be a trigger in “marine mines” laid by tumors to create delayed metastasis. This is but one of many cancer mechanisms involving YAP/TAZ (a central component of Hippo pathway) reviewed by Piccolo et al. in YAP/TAZ as master regulators in cancer, Nature Cancer, Dec 2022. A marine mine is laid in the sea…
