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Reversing T Cell Exhaustion: A New Role for IKZF1 Degradation
Read more: Reversing T Cell Exhaustion: A New Role for IKZF1 DegradationIn a recent publication in Cell Report Medicine (November 19, 2024), the authors explore a novel strategy to prevent T-cell exhaustion in the context of immuno-oncology. While adoptive cell therapies involving in vitro modified T cells can avoid immune exhaustion, the uncontrolled proliferation of these modified cells may lead to severe side effects, including potential…
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Single cell resource for outcomes of immunotherapy
Read more: Single cell resource for outcomes of immunotherapyA new paper in Cancer Cell should be a great resource in future work on immunotherapy. Immunotherapy is currently the best method to treat many cancers, but its success is mixed, and long-term side effects occur too. Investigating bulk data is hard without single cell reference because immune cells change gene expression dramatically during immune…
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Gluten-free diet can hurt you
Read more: Gluten-free diet can hurt youRecent paper by Morrison et al. shows that gluten-free diet (GFD) can cause dysbiosis with consequences like intestinal inflammation, food allergies etc. 25-50% of people have genetic susceptibility to Celiac Disease (CeD) that in a minority of cases leads to this disease, and GFD is currently the only treatment. How about the people with the…
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Signaling, cell differentiation and gut feeling (healthy or upset)
Read more: Signaling, cell differentiation and gut feeling (healthy or upset)Fukaya et al (Cell Reports 4/25/2023) investigate signaling between leukocytes in the gut with healthy biome, and with dysbiosis, and a mechanism that perpetuates intolerance of beneficial microbes and food allergies. To a non-specialist, this is a fascinating window to immune system, multiple cell types and the intricate system that results in decisions: friend or…
Jieun Jeong (정지은), Ph.D. 