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Gene regulatory networks: with cycles or without cycles?
Read more: Gene regulatory networks: with cycles or without cycles?Inferring gene regulatory networks (GRNs) from data such as knockout screens or single-cell assays has many applications. In particular, it helps identify biological mechanisms and enhances the discovery power of GWAS studies. New computational methods continue to improve these results. A gene regulatory network is a directed graph where each arc A → B indicates…
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DNA methylation: history and present
Read more: DNA methylation: history and presentMattei, Bailly, and Meissner provide an insightful review of CpG methylation in Trends in Genetics, tracing from its discovery in 1925 to current knowledge and outstanding questions. Originally a defense mechanism in bacteria against bacteriophages, DNA methylation has evolved significantly. What fascinates me most is the regulatory diversity of CpG methylation across the genome, which…
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News on pioneer transcription factors
Read more: News on pioneer transcription factorsHot new insights on pioneer transcription factors are reviewed by Barral and Zaret in the latest Trends in Genetics. Cells adopt new roles during cell differentiation or tumor disregulation, and it is well known that this change is guided by master transcription factors, known as pioneer factors (PFs) that can open/activate regulatory elements, active promoters…
Jieun Jeong (정지은), Ph.D. 