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News on pioneer transcription factors
Read more: News on pioneer transcription factorsHot new insights on pioneer transcription factors are reviewed by Barral and Zaret in the latest Trends in Genetics. Cells adopt new roles during cell differentiation or tumor disregulation, and it is well known that this change is guided by master transcription factors, known as pioneer factors (PFs) that can open/activate regulatory elements, active promoters…
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R-loops, dangerous regulation of genes
Read more: R-loops, dangerous regulation of genesAn R-loop reorganizes a small section of a chromosome: DNA strands are separated and one of them is bound to its complementary RNA sequence. They appear frequently during elongation, and for many genes, they are essential for their proper expression. However, exposed single DNA strand breaks easily, and sometimes the second strand breaks too. When…
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Understanding heterochromatin, new discoveries and guide to literature
Read more: Understanding heterochromatin, new discoveries and guide to literatureInterpreting gene expression and epigenetic data requires understanding heterochromatin assembly, regulatory mechanisms that can silence gene expression in wider chromosomal regions, and when those mechanisms are blocked, we can observe activation of gene expression. Shiv Greval reviews new discoveries and gives pointers to 204 references in “The molecular basis of heterochromatin assembly and epigenetic inheritance”,…
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Heterochromatin news
Read more: Heterochromatin newsCarraro et al, Molecular Cell, April 2023. Formation and maintenance of H3K9me3 regions involve assembly of new nucleosomes from H3-H4 histone dimers that include H3.3 histone with K9me3 modification. Until now, my image of post translational modifications of histones in nucleosomes was that a mechanism brings a chromatin complex to a location in the chromatin…
Jieun Jeong (정지은), Ph.D. 